Bioactive Compounds from Germinated Brown Rice Protect Cardiomyocytes Against Simulated Ischemic/Reperfusion Injury by Ameliorating Mitochondrial Dysfunction.

Demeekul, Kanokwan; Suthammarak, Wichit; Petchdee, Soontaree

Demeekul, Kanokwan; Suthammarak, Wichit; Petchdee, Soontaree.

Affiliation

Demeekul K; Graduate School, Program of Bio-Veterinary Science, Kasetsart University, Kamphaeng Saen, Nakorn Pathom, Thailand.
Suthammarak W; Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Petchdee S; Department of Large Animal and Wildlife Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, Kamphaeng Saen Campus, Nakorn Pathom, Thailand.

Drug Des Devel Ther ; 15: 1055-1066, 2021.

Article in En | MEDLINE | ID: mdl-33727794

Subject(s)

Cardiotonic Agents/pharmacology; Mitochondria/drug effects; Myocardial Reperfusion Injury/drug therapy; Myocytes, Cardiac/drug effects; Oryza/chemistry; Animals; Apoptosis/drug effects; Cardiotonic Agents/administration & dosage; Cardiotonic Agents/chemistry; Cells, Cultured; Dose-Response Relationship, Drug; Membrane Potential, Mitochondrial/drug effects; Mitochondria/metabolism; Molecular Structure; Myocardial Reperfusion Injury/metabolism; Myocardial Reperfusion Injury/pathology; Myocytes, Cardiac/metabolism; Myocytes, Cardiac/pathology; Rats; Structure-Activity Relationship

Key words

GBR; H9c2 cardiomyocyte; cardioprotection; germinated brown rice; ischemia reperfusion injury; mitochondria function

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oryza / Cardiotonic Agents / Myocardial Reperfusion Injury / Myocytes, Cardiac / Mitochondria Limits: Animals Language: En Journal: Drug Des Devel Ther Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2021 Document type: Article Affiliation country: Thailand

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