In vivo uptake of antisense oligonucleotide drugs predicted by ab initio quantum mechanical calculations.

Hansen, Henrik Frydenlund; Albaek, Nanna; Hansen, Bo Rode; Shim, Irene; Bohr, Henrik; Koch, Troels

Hansen, Henrik Frydenlund; Albaek, Nanna; Hansen, Bo Rode; Shim, Irene; Bohr, Henrik; Koch, Troels.

Affiliation

Hansen HF; Roche Innovation Center Copenhagen, Fremtidsvej 3, 2970, Hoersholm, Denmark.
Albaek N; Roche Innovation Center Copenhagen, Fremtidsvej 3, 2970, Hoersholm, Denmark.
Hansen BR; Roche Innovation Center Copenhagen, Fremtidsvej 3, 2970, Hoersholm, Denmark.
Shim I; Department of Chemistry, B-206-DTU, The Technical University of Denmark, 2800, Lyngby, Denmark.
Bohr H; Department of Chemical Engineering, B-229-DTU, The Technical University of Denmark, Lyngby, Denmark. hbohr@dtu.dk.
Koch T; Roche Innovation Center Copenhagen, Fremtidsvej 3, 2970, Hoersholm, Denmark.

Sci Rep ; 11(1): 6321, 2021 03 18.

Article in En | MEDLINE | ID: mdl-33737567

Subject(s)

Kidney/chemistry; Liver/chemistry; Oligonucleotides, Antisense/chemistry; Oligonucleotides/chemistry; Biochemical Phenomena; Electrons; Humans; Kidney/drug effects; Liver/drug effects; Oligonucleotides/pharmacology; Pharmaceutical Preparations/chemistry; Quantum Theory; RNA, Messenger/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligonucleotides / Oligonucleotides, Antisense / Kidney / Liver Type of study: Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Sci Rep Year: 2021 Document type: Article Affiliation country: Denmark Country of publication: United kingdom

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