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Effect of the dichloro-substitution on antiproliferative activity of phthalimide-thiazole derivatives. Rational design, synthesis, elastase, caspase 3/7, and EGFR tyrosine kinase activity and molecular modeling study.
Donarska, Beata; Switalska, Marta; Plazinski, Wojciech; Wietrzyk, Joanna; Laczkowski, Krzysztof Z.
Affiliation
  • Donarska B; Department of Chemical Technology and Pharmaceuticals, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Jurasza 2, 85-089 Bydgoszcz, Poland.
  • Switalska M; Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroclaw, Poland.
  • Plazinski W; Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek 8, 30-239 Cracow, Poland.
  • Wietrzyk J; Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroclaw, Poland.
  • Laczkowski KZ; Department of Chemical Technology and Pharmaceuticals, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Jurasza 2, 85-089 Bydgoszcz, Poland. Electronic address: krzysztof.laczkowski@cm.umk.pl.
Bioorg Chem ; 110: 104819, 2021 05.
Article in En | MEDLINE | ID: mdl-33752144
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phthalimides / Thiazoles / Drug Design / Enzyme Inhibitors / Antineoplastic Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: Bioorg Chem Year: 2021 Document type: Article Affiliation country: Poland Country of publication: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phthalimides / Thiazoles / Drug Design / Enzyme Inhibitors / Antineoplastic Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: Bioorg Chem Year: 2021 Document type: Article Affiliation country: Poland Country of publication: United States