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Lymphotoxin ß Receptor: a Crucial Role in Innate and Adaptive Immune Responses against Toxoplasma gondii.
Tersteegen, Anne; Sorg, Ursula R; Virgen-Slane, Richard; Helle, Marcel; Petzsch, Patrick; Dunay, Ildiko R; Köhrer, Karl; Degrandi, Daniel; Ware, Carl F; Pfeffer, Klaus.
Affiliation
  • Tersteegen A; Institute of Medical Microbiology and Hospital Hygiene, Heinrich Heine University, Düsseldorf, Germany.
  • Sorg UR; Institute of Inflammation and Neurodegeneration, Otto-von-Guericke-University, Magdeburg, Germany.
  • Virgen-Slane R; Institute of Medical Microbiology and Hospital Hygiene, Heinrich Heine University, Düsseldorf, Germany.
  • Helle M; Laboratory of Molecular Immunology, Infectious and Inflammatory Diseases Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.
  • Petzsch P; Institute of Medical Microbiology and Hospital Hygiene, Heinrich Heine University, Düsseldorf, Germany.
  • Dunay IR; Biological and Medical Research Center (BMFZ), Heinrich Heine University, Düsseldorf, Germany.
  • Köhrer K; Institute of Inflammation and Neurodegeneration, Otto-von-Guericke-University, Magdeburg, Germany.
  • Degrandi D; Biological and Medical Research Center (BMFZ), Heinrich Heine University, Düsseldorf, Germany.
  • Ware CF; Institute of Medical Microbiology and Hospital Hygiene, Heinrich Heine University, Düsseldorf, Germany.
  • Pfeffer K; Laboratory of Molecular Immunology, Infectious and Inflammatory Diseases Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.
Infect Immun ; 89(6)2021 05 17.
Article in En | MEDLINE | ID: mdl-33753412
The lymphotoxin ß receptor (LTßR) plays an essential role in the initiation of immune responses to intracellular pathogens. In mice, the LTßR is crucial for surviving acute toxoplasmosis; however, until now, a functional analysis was largely incomplete. Here, we demonstrate that the LTßR is a key regulator required for the intricate balance of adaptive immune responses. Toxoplasma gondii-infected LTßR-deficient (LTßR-/-) mice show globally altered interferon-γ (IFN-γ) regulation, reduced IFN-γ-controlled host effector molecule expression, impaired T cell functionality, and an absent anti-parasite-specific IgG response, resulting in a severe loss of immune control of the parasites. Reconstitution of LTßR-/- mice with toxoplasma immune serum significantly prolongs survival following T. gondii infection. Notably, analysis of RNA-seq data clearly indicates a specific effect of T. gondii infection on the B cell response and isotype switching. This study uncovers the decisive role of the LTßR in cytokine regulation and adaptive immune responses to control T. gondii.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Toxoplasma / Toxoplasmosis / Lymphotoxin beta Receptor / Adaptive Immunity / Host-Parasite Interactions / Immunity, Innate Type of study: Prognostic_studies Limits: Animals Language: En Journal: Infect Immun Year: 2021 Document type: Article Affiliation country: Germany Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Toxoplasma / Toxoplasmosis / Lymphotoxin beta Receptor / Adaptive Immunity / Host-Parasite Interactions / Immunity, Innate Type of study: Prognostic_studies Limits: Animals Language: En Journal: Infect Immun Year: 2021 Document type: Article Affiliation country: Germany Country of publication: United States