Inhibition of PTEN Ameliorates Secondary Hippocampal Injury and Cognitive Deficits after Intracerebral Hemorrhage: Involvement of AKT/FoxO3a/ATG-Mediated Autophagy.

Zhao, Manman; Gao, Junling; Cui, Changmeng; Zhang, Yanan; Jiang, Xiaohua; Cui, Jianzhong

Zhao, Manman; Gao, Junling; Cui, Changmeng; Zhang, Yanan; Jiang, Xiaohua; Cui, Jianzhong.

Affiliation

Zhao M; Department of Histology and Embryology, North China University of Science and Technology, Tangshan 063210, China.
Gao J; Department of Histology and Embryology, North China University of Science and Technology, Tangshan 063210, China.
Cui C; Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining 272000, China.
Zhang Y; Department of Histology and Embryology, North China University of Science and Technology, Tangshan 063210, China.
Jiang X; Department of Histology and Embryology, North China University of Science and Technology, Tangshan 063210, China.
Cui J; Department of Neurosurgery, Tangshan Gongren Hospital, Tangshan 063000, China.

Oxid Med Cell Longev ; 2021: 5472605, 2021.

Article in En | MEDLINE | ID: mdl-33777313

Subject(s)

Autophagy/drug effects; Cerebral Hemorrhage; Cognitive Dysfunction; Forkhead Box Protein O3/metabolism; Hippocampus; PTEN Phosphohydrolase/antagonists & inhibitors; Proto-Oncogene Proteins c-akt/metabolism; RNA, Small Interfering; Signal Transduction/drug effects; Animals; Cerebral Hemorrhage/drug therapy; Cerebral Hemorrhage/genetics; Cerebral Hemorrhage/metabolism; Cognitive Dysfunction/drug therapy; Cognitive Dysfunction/genetics; Cognitive Dysfunction/metabolism; Cognitive Dysfunction/pathology; Forkhead Box Protein O3/genetics; Hippocampus/injuries; Hippocampus/metabolism; Hippocampus/pathology; Male; PTEN Phosphohydrolase/genetics; PTEN Phosphohydrolase/metabolism; Proto-Oncogene Proteins c-akt/genetics; RNA, Small Interfering/genetics; RNA, Small Interfering/pharmacology; Rats; Rats, Sprague-Dawley

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Signal Transduction / Cerebral Hemorrhage / RNA, Small Interfering / PTEN Phosphohydrolase / Proto-Oncogene Proteins c-akt / Cognitive Dysfunction / Forkhead Box Protein O3 / Hippocampus Limits: Animals Language: En Journal: Oxid Med Cell Longev Journal subject: METABOLISMO Year: 2021 Document type: Article Affiliation country: China Country of publication: United States

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