Testosterone regulation on quiescin sulfhydryl oxidase 2 synthesis in the epididymis.
Reproduction
; 161(5): 593-602, 2021 04 20.
Article
in En
| MEDLINE
| ID: mdl-33784244
ABSTRACT
The epididymis is an androgen-responsive organ, whose structure and functions are modulated by the coordination between androgen and epididymal cues. Highly regulated molecular interaction within the epididymis is required to support viable sperm development necessary for subsequent fertilization. In the present study, we extended our earlier findings on a promising epididymal protein, quiescin sulfhydryl oxidase 2 (QSOX2), and demonstrated a positive correlation between testosterone and QSOX2 protein synthesis through the use of loss- and restore-of-function animal models. Moreover, based on transcriptomic analyses and 2D culture system, we determined that an additional polarized effect of glutamate is indispensable for the regulatory action of testosterone on QSOX2 synthesis. In conclusion, we propose noncanonical testosterone signaling supports epididymal QSOX2 protein synthesis, providing a novel perspective on the regulation of sperm maturation within the epididymis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sperm Maturation
/
Testosterone
/
Gene Expression Regulation
/
Glutamic Acid
/
Epididymis
/
Oxidoreductases Acting on Sulfur Group Donors
/
Glutamine
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Reproduction
Journal subject:
MEDICINA REPRODUTIVA
Year:
2021
Document type:
Article
Affiliation country:
Taiwan