Concerted outcome of metformin and low dose of radiation in modulation of cisplatin induced uremic encephalopathy via renal and neural preservation.

Hasan, Hesham Farouk; Rashed, Laila A; El Bakary, Nermeen M

Hasan, Hesham Farouk; Rashed, Laila A; El Bakary, Nermeen M.

Affiliation

Hasan HF; Radiation Biology Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt. Electronic address: hes_fa@yahoo.com.
Rashed LA; Department of Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt.
El Bakary NM; Radiation Biology Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt.

Life Sci ; 276: 119429, 2021 Jul 01.

Article in En | MEDLINE | ID: mdl-33785333

Subject(s)

Biomarkers/metabolism; Brain Diseases/prevention & control; Cisplatin/toxicity; Gamma Rays; Metformin/pharmacology; Neuroprotective Agents/pharmacology; Uremia/prevention & control; Animals; Antineoplastic Agents/toxicity; Brain Diseases/chemically induced; Brain Diseases/metabolism; Brain Diseases/pathology; Dose-Response Relationship, Radiation; Glutathione/metabolism; Hypoglycemic Agents/pharmacology; Male; NF-kappa B/metabolism; Oxidative Stress; Rats; Tumor Necrosis Factor-alpha/metabolism; Uremia/chemically induced; Uremia/metabolism; Uremia/pathology

Key words

Cisplatin; Low dose radiation; Metformin; Uremic encephalopathy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uremia / Brain Diseases / Biomarkers / Cisplatin / Neuroprotective Agents / Gamma Rays / Metformin Limits: Animals Language: En Journal: Life Sci Year: 2021 Document type: Article Country of publication: Netherlands

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