Antiviral Drug Ivermectin at Nanomolar Concentrations Inhibits Glycine-Induced Chloride Current in Rat Hippocampal Neurons.

Bukanova, J V; Solntseva, E I; Kondratenko, R V; Skrebitsky, V G

Bukanova, J V; Solntseva, E I; Kondratenko, R V; Skrebitsky, V G.

Affiliation

Bukanova JV; Research Center of Neurology, Moscow, Russia.
Solntseva EI; Research Center of Neurology, Moscow, Russia. synaptology@mail.ru.
Kondratenko RV; Research Center of Neurology, Moscow, Russia.
Skrebitsky VG; Research Center of Neurology, Moscow, Russia.

Bull Exp Biol Med ; 170(5): 649-653, 2021 Mar.

Article in En | MEDLINE | ID: mdl-33788116

Subject(s)

Chloride Channels/drug effects; Glycine/pharmacology; Ivermectin/pharmacology; Pyramidal Cells/drug effects; Action Potentials/drug effects; Animals; Antiviral Agents/pharmacology; Cells, Cultured; Chloride Channels/metabolism; Dose-Response Relationship, Drug; Hippocampus/cytology; Hippocampus/metabolism; Ion Channel Gating/drug effects; Patch-Clamp Techniques; Pyramidal Cells/physiology; Rats; Rats, Wistar; Receptors, Glycine/drug effects; Receptors, Glycine/metabolism

Key words

glycine receptor; hippocampus; ivermectin; patch clamp

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ivermectin / Pyramidal Cells / Chloride Channels / Glycine Limits: Animals Language: En Journal: Bull Exp Biol Med Year: 2021 Document type: Article Affiliation country: RUSSIA Country of publication: United States

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