A Histopathologic Scoring System for Perineural Invasion Correlates With Adverse Outcomes in Patients With Cutaneous Squamous Cell Carcinoma.
Dermatol Surg
; 47(4): 445-451, 2021 04 01.
Article
in En
| MEDLINE
| ID: mdl-33795563
ABSTRACT
BACKGROUND:
Perineural invasion (PNI) is a known risk factor for recurrence, metastasis, and death in cutaneous squamous cell carcinoma (cSCC). Current staging systems include PNI, but none define its extent or severity.OBJECTIVE:
To identify histopathologic features of cSCC with PNI that may be associated with adverse outcomes. MATERIALS ANDMETHODS:
This is a retrospective cohort study that included 45 patients with cSCC and PNI treated with surgical excision. Histopathologic slides were analyzed for 5 features of PNI largest affected nerve diameter, number of nerves affected, depth of nerve involvement, intra- versus extratumoral PNI, and focal versus circumferential PNI.RESULTS:
The median largest affected nerve diameter was 0.13 mm, and the median number of nerve structures involved was 4. After a median follow-up time of 24 months, 6 patients developed adverse outcomes, including 2 local recurrences, 4 metastases, and 2 tumor-related deaths. Univariate logistic regression analysis revealed that nerve diameter and number of affected nerves were significantly associated with adverse outcome. A composite PNI score, calculated from 5 histopathologic features, was the strongest predictor of adverse outcome (p = .020).CONCLUSION:
Histopathologic features of PNI can be quantified with a composite PNI score that is significantly associated with adverse outcomes in cSCC.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peripheral Nerves
/
Skin Neoplasms
/
Carcinoma, Squamous Cell
/
Neoplasm Staging
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Dermatol Surg
Journal subject:
DERMATOLOGIA
Year:
2021
Document type:
Article