Perforated coated tablets for controlled release of drugs at a constant rate.
J Pharm Sci
; 77(4): 322-4, 1988 Apr.
Article
in En
| MEDLINE
| ID: mdl-3379590
ABSTRACT
Tablets with a central hole and a water-impermeable coating were prepared. These perforated coated tablets (PCTs) dissolve and release drug through the central hole only. In vitro release of the model drugs sodium benzoate and benzamide from PCTs occurred at a constant rate up to 80% release. The zero-order release rate varies with hole size, drug solubility, drug concentration, diluent solubility, and binder concentration. These results demonstrate that the PCT design can be used to prepare drug delivery devices which release at controllable constant rates.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tablets, Enteric-Coated
Language:
En
Journal:
J Pharm Sci
Year:
1988
Document type:
Article