Mast Cells and Proteins Related to Myofibroblast Differentiation (PAR-2, IL-6, and TGFß1) in Salivary Cancers: A Preliminary Study.
Appl Immunohistochem Mol Morphol
; 29(7): e57-e67, 2021 08 01.
Article
in En
| MEDLINE
| ID: mdl-33797435
ABSTRACT
Salivary gland neoplasms represent an important group of cancers in the head and neck and myoepithelial cells play a key role on the development these tumors. This study evaluated the distribution of mast cells and related proteins (PAR-2, TGFß1, IL-6) to the myofibroblastic differentiation in malignant tumors of salivary glands with and without myoepithelial differentiation. Immunohistochemical assessement for tryptase mast cells, SMA, PAR-2, TGFß1, IL-6 was performed in 10 cases of polymorphous low-grade adenocarcinoma, 14 cases of mucoepidermoid carcinoma (MEC) and 10 cases of adenoid cystic carcinoma. When the density of mast cells were compared between tumors, their density was significantly higher in MEC (P=0.08). Tumors with high expression of PAR-2 (79.4%) exhibited a high density of mast cells. Myofibroblasts were more frequent in malignant tumors with low expression (<50%) of cell masts. Individual analysis of the tumors showed no significant difference between the expression of PAR-2, IL-6, TGFß1, and myofibroblasts. When the density of mast cells, myofibroblasts and the expression of PAR-2 protein, IL-6, and TGFß1 were compared, it was no statistically significant difference between tumors with and without myoepithelial differentiation. The results of present study suggest a possible participation of mast cells and especially of PAR-2 in the development and progression of malignant salivary cancers, regardless of myoepithelial content.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Salivary Gland Neoplasms
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Cell Differentiation
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Interleukin-6
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Receptor, PAR-2
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Transforming Growth Factor beta1
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Myofibroblasts
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Mast Cells
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Neoplasm Proteins
Limits:
Humans
Language:
En
Journal:
Appl Immunohistochem Mol Morphol
Journal subject:
BIOLOGIA MOLECULAR
/
HISTOCITOQUIMICA
Year:
2021
Document type:
Article