Skp2 and Slug Are Coexpressed in Aggressive Prostate Cancer and Inhibited by Neddylation Blockade.

Mickova, Alena; Kharaishvili, Gvantsa; Kurfurstova, Daniela; Gachechiladze, Mariam; Kral, Milan; Vacek, Ondrej; Pokryvkova, Barbora; Mistrik, Martin; Soucek, Karel; Bouchal, Jan

Mickova, Alena; Kharaishvili, Gvantsa; Kurfurstova, Daniela; Gachechiladze, Mariam; Kral, Milan; Vacek, Ondrej; Pokryvkova, Barbora; Mistrik, Martin; Soucek, Karel; Bouchal, Jan.

Affiliation

Mickova A; Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, 779 00 Olomouc, Czech Republic.
Kharaishvili G; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, 779 00 Olomouc, Czech Republic.
Kurfurstova D; Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, 779 00 Olomouc, Czech Republic.
Gachechiladze M; Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, 779 00 Olomouc, Czech Republic.
Kral M; Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, 779 00 Olomouc, Czech Republic.
Vacek O; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, 779 00 Olomouc, Czech Republic.
Pokryvkova B; Department of Urology, University Hospital, 779 00 Olomouc, Czech Republic.
Mistrik M; Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, 612 65 Brno, Czech Republic.
Soucek K; International Clinical Research Center, Center for Biomolecular and Cellular Engineering, St. Anne's University Hospital in Brno, 602 00 Brno, Czech Republic.
Bouchal J; Department of Experimental Biology, Faculty of Science, Masaryk University, 625 00 Brno, Czech Republic.

Int J Mol Sci ; 22(6)2021 Mar 11.

Article in En | MEDLINE | ID: mdl-33799604

Subject(s)

NEDD8 Protein/genetics; Prostatic Neoplasms/genetics; Protein Processing, Post-Translational; S-Phase Kinase-Associated Proteins/genetics; Snail Family Transcription Factors/genetics; Antigens, CD/genetics; Antigens, CD/metabolism; Antineoplastic Agents/pharmacology; Cadherins/genetics; Cadherins/metabolism; Cell Line, Tumor; Cell Survival/drug effects; Cyclin-Dependent Kinase Inhibitor p27/genetics; Cyclin-Dependent Kinase Inhibitor p27/metabolism; Cyclopentanes/pharmacology; Docetaxel/pharmacology; Epithelial-Mesenchymal Transition/genetics; Gene Expression Regulation, Neoplastic; Humans; Lymphatic Metastasis; Male; NEDD8 Protein/metabolism; Neoplasm Grading; PC-3 Cells; Prostate/metabolism; Prostate/pathology; Prostatic Neoplasms/metabolism; Prostatic Neoplasms/pathology; Pyrimidines/pharmacology; RNA, Small Interfering/genetics; RNA, Small Interfering/metabolism; Receptors, Androgen/genetics; Receptors, Androgen/metabolism; S-Phase Kinase-Associated Proteins/antagonists & inhibitors; S-Phase Kinase-Associated Proteins/metabolism; Snail Family Transcription Factors/metabolism

Key words

Skp2 (S-phase kinase-associated protein 2); Slug; immunohistochemistry; multiplex; neddylation; prostate cancer

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Protein Processing, Post-Translational / S-Phase Kinase-Associated Proteins / Snail Family Transcription Factors / NEDD8 Protein Language: En Journal: Int J Mol Sci Year: 2021 Document type: Article Affiliation country: Czech Republic Country of publication: Switzerland

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