SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon Response.

Oh, Soo Jin; Shin, Ok Sarah

Oh, Soo Jin; Shin, Ok Sarah.

Affiliation

Oh SJ; BK21 Graduate Program, Department of Biomedical Sciences, College of Medicine, Korea University Guro Hospital, Seoul 08308, Korea.
Shin OS; BK21 Graduate Program, Department of Biomedical Sciences, College of Medicine, Korea University Guro Hospital, Seoul 08308, Korea.

Cells ; 10(3)2021 03 02.

Article in En | MEDLINE | ID: mdl-33801464

Subject(s)

Coronavirus Nucleocapsid Proteins/metabolism; DEAD Box Protein 58/metabolism; Interferons/metabolism; Receptors, Immunologic/metabolism; SARS-CoV-2/metabolism; DEAD Box Protein 58/genetics; Host-Pathogen Interactions/genetics; Humans; Interferon Regulatory Factor-3/genetics; Interferon Regulatory Factor-3/metabolism; Interferon Type I/genetics; Interferon Type I/metabolism; Interferon-gamma/genetics; Interferon-gamma/metabolism; Interferons/genetics; Orthomyxoviridae/genetics; Orthomyxoviridae/metabolism; Phosphoproteins/metabolism; Poly C/pharmacology; Poly I/pharmacology; Promoter Regions, Genetic; Protein Serine-Threonine Kinases/genetics; Protein Serine-Threonine Kinases/metabolism; Receptors, Immunologic/genetics; SARS-CoV-2/genetics; Signal Transduction/drug effects; Signal Transduction/genetics; Transcription Factors/metabolism; Tripartite Motif Proteins/metabolism; Ubiquitin-Protein Ligases/metabolism; Up-Regulation; Zika Virus/genetics; Zika Virus/metabolism

Key words

RIG-I like receptors; SARS-CoV-2 N protein; antiviral immune response; coronavirus disease 2019; interferon

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Immunologic / Interferons / DEAD Box Protein 58 / Coronavirus Nucleocapsid Proteins / SARS-CoV-2 Limits: Humans Language: En Journal: Cells Year: 2021 Document type: Article Country of publication: Switzerland

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