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Hyalectanase Activities by the ADAMTS Metalloproteases.
Fontanil, Tania; Mohamedi, Yamina; Espina-Casado, Jorge; Obaya, Álvaro J; Cobo, Teresa; Cal, Santiago.
Affiliation
  • Fontanil T; Departamento de Bioquímica y Biología Molecular, Universidad de Oviedo, 33006 Oviedo, Spain.
  • Mohamedi Y; Departamento de Investigación, Instituto Ordóñez, 33012 Oviedo, Spain.
  • Espina-Casado J; Departamento de Bioquímica y Biología Molecular, Universidad de Oviedo, 33006 Oviedo, Spain.
  • Obaya ÁJ; Departamento de Química Física y Analítica, Universidad de Oviedo, 33006 Oviedo, Spain.
  • Cobo T; Departamento de Biología Funcional, Área de Fisiología, Universidad de Oviedo, 33006 Oviedo, Spain.
  • Cal S; Instituto Universitario de Oncología, IUOPA, Universidad de Oviedo, 33006 Oviedo, Spain.
Int J Mol Sci ; 22(6)2021 Mar 15.
Article in En | MEDLINE | ID: mdl-33804223
The hyalectan family is composed of the proteoglycans aggrecan, versican, brevican and neurocan. Hyalectans, also known as lecticans, are components of the extracellular matrix of different tissues and play essential roles in key biological processes including skeletal development, and they are related to the correct maintenance of the vascular and central nervous system. For instance, hyalectans participate in the organization of structures such as perineural nets and in the regulation of neurite outgrowth or brain recovery following a traumatic injury. The ADAMTS (A Disintegrin and Metalloprotease domains, with thrombospondin motifs) family consists of 19 secreted metalloproteases. These enzymes also perform important roles in the structural organization and function of the extracellular matrix through interactions with other matrix components or as a consequence of their catalytic activity. In this regard, some of their preferred substrates are the hyalectans. In fact, ADAMTSs cleave hyalectans not only as a mechanism for clearance or turnover of proteoglycans but also to generate bioactive fragments which display specific functions. In this article we review some of the physiological and pathological effects derived from cleavages of hyalectans mediated by ADAMTSs.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Extracellular Matrix / Hyalectins / ADAMTS Proteins / Neuronal Outgrowth Limits: Humans Language: En Journal: Int J Mol Sci Year: 2021 Document type: Article Affiliation country: Spain Country of publication: Switzerland

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Extracellular Matrix / Hyalectins / ADAMTS Proteins / Neuronal Outgrowth Limits: Humans Language: En Journal: Int J Mol Sci Year: 2021 Document type: Article Affiliation country: Spain Country of publication: Switzerland