Hepatitis C Viral Replication Complex.
Viruses
; 13(3)2021 03 22.
Article
in En
| MEDLINE
| ID: mdl-33809897
ABSTRACT
The life cycle of the hepatitis C virus (HCV) can be divided into several stages, including viral entry, protein translation, RNA replication, viral assembly, and release. HCV genomic RNA replication occurs in the replication organelles (RO) and is tightly linked to ER membrane alterations containing replication complexes (proteins NS3 to NS5B). The amplification of HCV genomic RNA could be regulated by the RO biogenesis, the viral RNA structure (i.e., cis-acting replication elements), and both viral and cellular proteins. Studies on HCV replication have led to the development of direct-acting antivirals (DAAs) targeting the replication complex. This review article summarizes the viral and cellular factors involved in regulating HCV genomic RNA replication and the DAAs that inhibit HCV replication.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Virus Replication
/
Hepatitis C
/
Hepacivirus
/
Virus Assembly
Limits:
Humans
Language:
En
Journal:
Viruses
Year:
2021
Document type:
Article
Affiliation country:
Taiwan