Roles of phosphatidyl inositol 3 kinase gamma (PI3Kγ) in respiratory diseases.
Cell Stress
; 5(4): 40-51, 2021 Mar 08.
Article
in En
| MEDLINE
| ID: mdl-33821232
ABSTRACT
Phosphatidyl inositol 3 kinase gamma (PI3Kγ) is expressed in all the cell types that are involved in airway inflammation and disease, including not only leukocytes, but also structural cells, where it is expressed at very low levels under physiological conditions, while is significantly upregulated after stress. In the airways, PI3Kγ behaves as a trigger or a controller, depending on the pathological context. In this review, the contribution of PI3Kγ in a plethora of respiratory diseases, spanning from acute lung injury, pulmonary fibrosis, asthma, cystic fibrosis and response to both bacterial and viral pathogens, will be commented.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Cell Stress
Year:
2021
Document type:
Article
Affiliation country:
Italy