Calcineurin inhibitors suppress acute graft-versus-host disease via NFAT-independent inhibition of T cell receptor signaling.

Otsuka, Shizuka; Melis, Nicolas; Gaida, Matthias M; Dutta, Debjani; Weigert, Roberto; Ashwell, Jonathan D

Otsuka, Shizuka; Melis, Nicolas; Gaida, Matthias M; Dutta, Debjani; Weigert, Roberto; Ashwell, Jonathan D.

Affiliation

Otsuka S; Laboratory of Immune Cell Biology and.
Melis N; Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Gaida MM; Institute of Pathology, University Medical Center Mainz, Mainz, Germany.
Dutta D; Laboratory of Immune Cell Biology and.
Weigert R; Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Ashwell JD; Laboratory of Immune Cell Biology and.

J Clin Invest ; 131(11)2021 06 01.

Article in En | MEDLINE | ID: mdl-33822776

Subject(s)

CD8-Positive T-Lymphocytes/immunology; Calcineurin Inhibitors/pharmacology; Cyclosporine/pharmacology; Graft vs Host Disease/drug therapy; NFATC Transcription Factors/immunology; Receptors, Antigen, T-Cell/immunology; Signal Transduction/immunology; Acute Disease; Animals; Graft vs Host Disease/genetics; Graft vs Host Disease/immunology; Mice; Mice, Knockout; NFATC Transcription Factors/genetics; Receptors, Antigen, T-Cell/genetics; Signal Transduction/genetics

Key words

Immunology; Organ transplantation; Signal transduction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Antigen, T-Cell / Signal Transduction / Cyclosporine / CD8-Positive T-Lymphocytes / NFATC Transcription Factors / Calcineurin Inhibitors / Graft vs Host Disease Limits: Animals Language: En Journal: J Clin Invest Year: 2021 Document type: Article Country of publication: United States

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