Investigating hypotheses of neurodegeneration by learning dynamical systems of protein propagation in the brain.
Neuroimage
; 235: 117980, 2021 07 15.
Article
in En
| MEDLINE
| ID: mdl-33823273
ABSTRACT
We introduce a theoretical framework for estimating, comparing and interpreting mechanistic hypotheses on long term protein propagation across brain networks in neurodegenerative disorders (ND). The model is expressed within a Bayesian non-parametric regression setting, where mechanisms of protein dynamics are inferred by means of gradient matching on dynamical systems (DS). The Bayesian formalism, combined with stochastic variational inference, naturally allows for model comparison via assessment of model evidence, while providing uncertainty quantification of causal relationship underlying protein progressions. When applied to in-vivo AV45-PET brain imaging data measuring topographic amyloid deposition in Alzheimer's disease (AD), our model identified the mechanisms of accumulation, clearance and propagation as the best suited DS for bio-mechanical description of amyloid dynamics in AD, enabling realistic and accurate personalized simulation of amyloidosis.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Disease Progression
/
Neurodegenerative Diseases
/
Neuroimaging
/
Models, Theoretical
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Neuroimage
Journal subject:
DIAGNOSTICO POR IMAGEM
Year:
2021
Document type:
Article