Recent advances in computational metabolite structure predictions and altered metabolic pathways assessment to inform drug development processes.

Schleiff, Mary Alexandra; Dhaware, Deepika; Sodhi, Jasleen K

Schleiff, Mary Alexandra; Dhaware, Deepika; Sodhi, Jasleen K.

Affiliation

Schleiff MA; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Dhaware D; Biotransformation and ADME, Research and Development, Orion Corporation, Espoo, Finland.
Sodhi JK; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, CA, USA.

Drug Metab Rev ; 53(2): 173-187, 2021 05.

Article in En | MEDLINE | ID: mdl-33840322

Subject(s)

Drug Development; Metabolic Networks and Pathways; Animals; Drug Interactions; Humans; Inactivation, Metabolic; Metabolic Clearance Rate

Key words

Computational modeling; cytochromes P450; drugdrug interactions; genetic polymorphisms; interindividual variability; metabolism; sites of metabolism (SoM)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Metabolic Networks and Pathways / Drug Development Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Drug Metab Rev Year: 2021 Document type: Article Affiliation country: United States Country of publication: United kingdom

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