The mechanism by which imeglimin inhibits gluconeogenesis in rat liver cells.

Vial, Guillaume; Lamarche, Frédéric; Cottet-Rousselle, Cécile; Hallakou-Bozec, Sophie; Borel, Anne-Laure; Fontaine, Eric

Vial, Guillaume; Lamarche, Frédéric; Cottet-Rousselle, Cécile; Hallakou-Bozec, Sophie; Borel, Anne-Laure; Fontaine, Eric.

Affiliation

Vial G; Université Grenoble Alpes, Grenoble, France.
Lamarche F; Inserm U 1042, Grenoble, France.
Cottet-Rousselle C; Université Grenoble Alpes, LBFA, Grenoble, France.
Hallakou-Bozec S; Inserm U 1055, LBFA, Grenoble, France.
Borel AL; Université Grenoble Alpes, LBFA, Grenoble, France.
Fontaine E; Inserm U 1055, LBFA, Grenoble, France.

Endocrinol Diabetes Metab ; 4(2): e00211, 2021 04.

Article in En | MEDLINE | ID: mdl-33855213

Subject(s)

Gluconeogenesis/drug effects; Hepatocytes/metabolism; Hypoglycemic Agents/pharmacology; Triazines/pharmacology; Adenosine Diphosphate/metabolism; Adenosine Triphosphatases/metabolism; Adenosine Triphosphate/metabolism; Animals; Cells, Cultured; Male; Membrane Potential, Mitochondrial/drug effects; Metformin/pharmacology; Mitochondria, Liver/metabolism; Oxidation-Reduction/drug effects; Oxygen Consumption/drug effects; Rats, Wistar

Key words

complex I; imeglimin; metformin; mitochondria

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triazines / Hepatocytes / Gluconeogenesis / Hypoglycemic Agents Limits: Animals Language: En Journal: Endocrinol Diabetes Metab Year: 2021 Document type: Article Affiliation country: France Country of publication: United kingdom

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