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Response to Comment on "Circadian rhythms in the absence of the clock gene Bmal1".
Ray, Sandipan; Valekunja, Utham K; Stangherlin, Alessandra; Howell, Steven A; Snijders, Ambrosius P; Damodaran, Gopinath; Reddy, Akhilesh B.
Affiliation
  • Ray S; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Valekunja UK; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Stangherlin A; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Howell SA; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Snijders AP; Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.
  • Damodaran G; Francis Crick Institute, London NW1 1AT, UK.
  • Reddy AB; Francis Crick Institute, London NW1 1AT, UK.
Science ; 372(6539)2021 04 16.
Article in En | MEDLINE | ID: mdl-33859002
ABSTRACT
Ness-Cohn et al claim that our observations of transcriptional circadian rhythms in the absence of the core clock gene Bmal1 in mouse skin fibroblast cells are supported by inadequate evidence. They claim that they were unable to reproduce some of the original findings with their reanalysis. We disagree with their analyses and outlook.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Circadian Rhythm / ARNTL Transcription Factors Limits: Animals Language: En Journal: Science Year: 2021 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Circadian Rhythm / ARNTL Transcription Factors Limits: Animals Language: En Journal: Science Year: 2021 Document type: Article Affiliation country: United States