A fluorescent nanobiocide based on ROS generation for eliminating pathogenic and multidrug-resistant bacteria.
J Mater Chem B
; 9(17): 3689-3695, 2021 05 05.
Article
in En
| MEDLINE
| ID: mdl-33861292
ABSTRACT
Exogenous reactive oxygen species (ROS) generation is a promising antibacterial strategy. The short diffusion distance coupled with the transient existence of ROS restrict their precise release at inflammation sites, so it is imperative to regulate the reactive sites of ROS donors. In this work, we developed a glycomimetic-decorated fluorescent nanobiocide to mediate the release of ROS generated from CuInS/ZnS quantum dots. The introduction of glycomimetics innovatively improved the biocompatibility of the hydrophobic quantum dots, allowing pathogenic bacteria to be targeted. The functionalized CuInS/ZnS quantum dots allowed simultaneous fluorescent reporting and sterilization under 660 nm illumination. Moreover, the nanobiocide can serve as a cell-binding glue causing bacterial aggregation, disrupting bacterial adhesion to host cells and inhibiting biofilm formation. Collectively, this work indicated the far-reaching future of ROS-generating biomimetic design for multifunctional nanobiocides to combat bacterial infections.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quantum Dots
/
Fluorescent Dyes
/
Infections
/
Anti-Bacterial Agents
Limits:
Animals
/
Humans
Language:
En
Journal:
J Mater Chem B
Year:
2021
Document type:
Article
Affiliation country:
China