Calcium-independent phospholipase A2 inhibitor produces an analgesic effect in a rat model of neuropathic pain by reducing central sensitization in the dorsal horn.

Gwak, Young Seob; Chen, Guanxing; Abdi, Salahadin; Kim, Hee Kee

Gwak, Young Seob; Chen, Guanxing; Abdi, Salahadin; Kim, Hee Kee.

Affiliation

Gwak YS; Department of Anesthesiology and Perioperative Care, University of California, Irvine, CA, USA.
Chen G; Department of Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Abdi S; Department of Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Kim HK; Department of Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Neurol Res ; 43(8): 683-692, 2021 Aug.

Article in En | MEDLINE | ID: mdl-33866950

Subject(s)

Analgesics/administration & dosage; Enzyme Inhibitors/administration & dosage; Neuralgia/drug therapy; Phospholipases A2, Calcium-Independent/antagonists & inhibitors; Spinal Cord Dorsal Horn/drug effects; Administration, Oral; Animals; Anti-Inflammatory Agents/administration & dosage; Arachidonic Acids/administration & dosage; Injections, Spinal; Male; Neuralgia/enzymology; Phospholipases A2, Calcium-Independent/metabolism; Prednisolone/administration & dosage; Rats; Rats, Sprague-Dawley; Spinal Cord Dorsal Horn/enzymology

Key words

Bromoenolactone; calcium-independent cytosolic phospholipase a2; neuropathic pain; spinal nerve ligation; wide dynamic range

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enzyme Inhibitors / Phospholipases A2, Calcium-Independent / Spinal Cord Dorsal Horn / Analgesics / Neuralgia Limits: Animals Language: En Journal: Neurol Res Year: 2021 Document type: Article Affiliation country: United States Country of publication: United kingdom

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