Spinal anesthesia in a patient on monoclonal antibody treatment: a poisoned chalice? A case report.
Reg Anesth Pain Med
; 46(9): 828-830, 2021 09.
Article
in En
| MEDLINE
| ID: mdl-33875579
ABSTRACT
BACKGROUND:
Paraplegia is a rare complication of spinal anesthesia. CASE PRESENTATION We report a case of a 68-year-old man who developed postoperative paraplegia and hypoesthesia after spinal anesthesia for an otherwise uncomplicated transurethral resection of the prostate. Acute transverse myelitis was diagnosed based on urgent MRI. A prior history of similar though less severe neurological symptoms after obinutuzumab treatment for follicular lymphoma suggested a potential causative role for obinutuzumab, a novel monoclonal antibody that has not been associated with such devastating neurological side effects yet. High-dose steroid treatment partially attenuated the symptoms, but debilitating hypoesthesia and motor deficit remained present 3 months postoperatively.CONCLUSION:
The presented case warrants caution when performing neuraxial anesthesia in patients on monoclonal antibody therapies.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Poisons
/
Transurethral Resection of Prostate
/
Anesthesia, Spinal
Limits:
Aged
/
Humans
/
Male
Language:
En
Journal:
Reg Anesth Pain Med
Journal subject:
ANESTESIOLOGIA
/
NEUROLOGIA
/
PSICOFISIOLOGIA
Year:
2021
Document type:
Article
Affiliation country:
Belgium