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A new 26-norlanostane from Phlogacanthus turgidus growing in Vietnam.
Tri, Mai Dinh; Phat, Nguyen Tan; Trung, Nguyen Tien; Phan, Cam-Tu D; Minh, Phan Nhat; Chi, Mai Thanh; Nguyen, Thi-Phuong; Dang, Chi Hien; Hong Truong, Luu; Pham, Nguyen Kim Tuyen; Mai, Tran Thi Ngoc; Duong, Thuc-Huy.
Affiliation
  • Tri MD; Vietnam Academy of Science and Technology, Graduate University of Science and Technology, Ha noi 11355, Vietnam.
  • Phat NT; Institute of Chemical Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City 71515, Vietnam.
  • Trung NT; Vietnam Academy of Science and Technology, Graduate University of Science and Technology, Ha noi 11355, Vietnam.
  • Phan CD; Institute of Chemical Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City 71515, Vietnam.
  • Minh PN; Laboratory of Computational Chemistry and Modelling (LCCM), Quy Nhon University, Quy Nhon 55100, Vietnam.
  • Chi MT; Laboratory of Computational Chemistry and Modelling (LCCM), Quy Nhon University, Quy Nhon 55100, Vietnam.
  • Nguyen TP; Institute of Chemical Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City 71515, Vietnam.
  • Dang CH; Vietnam Academy of Science and Technology, Graduate University of Science and Technology, Ha noi 11355, Vietnam.
  • Hong Truong L; Institute of Chemical Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City 71515, Vietnam.
  • Pham NKT; NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City 72806, Vietnam.
  • Mai TTN; Vietnam Academy of Science and Technology, Graduate University of Science and Technology, Ha noi 11355, Vietnam.
  • Duong TH; Institute of Chemical Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City 71515, Vietnam.
J Asian Nat Prod Res ; 24(2): 196-202, 2022 Feb.
Article in En | MEDLINE | ID: mdl-33876656
Chemical investigation on chloroform extract of Phlogacanthus turgidus led to the isolation of one new compound namely turgidol, together with five known triterpenoids, lupeol, lupenone, betulin, betulinic acid, and taraxerol. Their structures and stereochemistry have been determined by 1 D and 2 D NMR analysis, high resolution mass spectrometry, and compared with those in literatures. The relative configuration of turgidol was defined using DFT-NMR chemical shift calculations and subsequent DP4+ probability method. Turgidol, betulin, and betulinic acid were evaluated for cytotoxic activity toward K562 cancer cell line and the alpha-glucosidase inhibition.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triterpenes / Acanthaceae Limits: Humans Country/Region as subject: Asia Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2022 Document type: Article Affiliation country: Vietnam Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triterpenes / Acanthaceae Limits: Humans Country/Region as subject: Asia Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2022 Document type: Article Affiliation country: Vietnam Country of publication: United kingdom