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Caveolar peroxynitrite formation impairs endothelial TRPV4 channels and elevates pulmonary arterial pressure in pulmonary hypertension.
Daneva, Zdravka; Marziano, Corina; Ottolini, Matteo; Chen, Yen-Lin; Baker, Thomas M; Kuppusamy, Maniselvan; Zhang, Aimee; Ta, Huy Q; Reagan, Claire E; Mihalek, Andrew D; Kasetti, Ramesh B; Shen, Yuanjun; Isakson, Brant E; Minshall, Richard D; Zode, Gulab S; Goncharova, Elena A; Laubach, Victor E; Sonkusare, Swapnil K.
Affiliation
  • Daneva Z; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908.
  • Marziano C; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908.
  • Ottolini M; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908.
  • Chen YL; Department of Pharmacology, University of Virginia, Charlottesville, VA 22908.
  • Baker TM; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908.
  • Kuppusamy M; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908.
  • Zhang A; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908.
  • Ta HQ; Department of Surgery, University of Virginia, Charlottesville, VA 22908.
  • Reagan CE; Department of Surgery, University of Virginia, Charlottesville, VA 22908.
  • Mihalek AD; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908.
  • Kasetti RB; Department of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, VA 22908.
  • Shen Y; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107.
  • Isakson BE; North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107.
  • Minshall RD; Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15213.
  • Zode GS; Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213.
  • Goncharova EA; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213.
  • Laubach VE; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213.
  • Sonkusare SK; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908.
Proc Natl Acad Sci U S A ; 118(17)2021 04 27.
Article in En | MEDLINE | ID: mdl-33879616
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endothelium, Vascular / Caveolae / Peroxynitrous Acid / TRPV Cation Channels / Pulmonary Arterial Hypertension Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2021 Document type: Article Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endothelium, Vascular / Caveolae / Peroxynitrous Acid / TRPV Cation Channels / Pulmonary Arterial Hypertension Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2021 Document type: Article Country of publication: United States