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Association of Age, Antipsychotic Medication, and Symptom Severity in Schizophrenia With Proton Magnetic Resonance Spectroscopy Brain Glutamate Level: A Mega-analysis of Individual Participant-Level Data.
Merritt, Kate; McGuire, Philip K; Egerton, Alice; Aleman, André; Block, Wolfgang; Bloemen, Oswald J N; Borgan, Faith; Bustillo, Juan R; Capizzano, Aristides A; Coughlin, Jennifer Marie; De la Fuente-Sandoval, Camilo; Demjaha, Arsime; Dempster, Kara; Do, Kim Q; Du, Fei; Falkai, Peter; Galinska-Skok, Beata; Gallinat, Jurgen; Gasparovic, Charles; Ginestet, Cedric E; Goto, Naoki; Graff-Guerrero, Ariel; Ho, Beng Choon; Howes, Oliver D; Jauhar, Sameer; Jeon, Peter; Kato, Tadafumi; Kaufmann, Charles A; Kegeles, Lawrence S; Keshavan, Matcheri; Kim, Sang-Young; Kunugi, Hiroshi; Lauriello, John; Liemburg, Edith Jantine; Mcilwain, Meghan E; Modinos, Gemma; Mouchlianitis, Elias D; Nakamura, Jun; Nenadic, Igor; Öngür, Dost; Ota, Miho; Palaniyappan, Lena; Pantelis, Christos; Plitman, Eric; Posporelis, Sotirios; Purdon, Scot E; Reichenbach, Jürgen R; Renshaw, Perry F; Russell, Bruce R; Sawa, Akira.
Affiliation
  • Merritt K; Division of Psychiatry, Institute of Mental Health, UCL, London, United Kingdom.
  • McGuire PK; Psychosis Studies Department, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.
  • Egerton A; Psychosis Studies Department, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.
  • Block W; Center for Brain Disorder and Cognitive Science, Shenzhen University, Shenzhen, China.
  • Bloemen OJN; University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Borgan F; Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, Germany.
  • Bustillo JR; Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands.
  • Capizzano AA; Psychosis Studies Department, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.
  • Coughlin JM; Department of Psychiatry and Behavioral Sciences, Center for Psychiatric Research, University of New Mexico School of Medicine, Albuquerque.
  • De la Fuente-Sandoval C; Department of Radiology, Division of Neuroradiology, University of Michigan, Ann Arbor.
  • Demjaha A; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  • Dempster K; Laboratory of Experimental Psychiatry, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.
  • Do KQ; Neuropsychiatry Department, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.
  • Du F; Psychosis Studies Department, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.
  • Falkai P; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Galinska-Skok B; Center for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital-CHUV, Prilly-Lausanne, Switzerland.
  • Gallinat J; Psychotic Disorders Division, McLean Hospital, Harvard Medical School, Belmont, Massachusetts.
  • Gasparovic C; Department of Psychiatry, University Hospital, LMU Munich, Munich, Germany.
  • Ginestet CE; Department of Psychiatry, Medical University of Bialystok, Bialystok, Poland.
  • Goto N; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf (UKE), Germany.
  • Graff-Guerrero A; Mind Research Network, Albuquerque, New Mexico.
  • Ho BC; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience King's College London, London, United Kingdom.
  • Howes OD; Department of Psychiatry, Kokura Gamo Hospital, Kitakyushu, Fukuoka, Japan.
  • Jauhar S; Multimodal Neuroimaging Schizophrenia Group, Research Imaging Centre, Geriatric Mental Health Program at Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
  • Jeon P; Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City.
  • Kato T; Psychosis Studies Department, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.
  • Kaufmann CA; Psychosis Studies Department, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.
  • Kegeles LS; Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada.
  • Keshavan M; Department of Psychiatry and Behavioral Science, Juntendo University Graduate School of Medicine, Tokyo, Japan.
  • Kim SY; Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York.
  • Kunugi H; Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York.
  • Lauriello J; Harvard Medical School, Boston, Massachusetts.
  • Liemburg EJ; Philips Healthcare, Seoul, Republic of Korea.
  • Mcilwain ME; National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
  • Modinos G; Jefferson Health-Sidney Kimmel Medical College, Philadelphia, Pennsylvania.
  • Mouchlianitis ED; Rob Giel Research Center, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands.
  • Nakamura J; School of Pharmacy, University of Auckland, Grafton, Auckland, New Zealand.
  • Nenadic I; Psychosis Studies Department, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.
  • Öngür D; Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neuroscience, De Crespigny Park, London, United Kingdom.
  • Ota M; Psychosis Studies Department, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.
  • Palaniyappan L; Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan.
  • Pantelis C; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf (UKE), Germany.
  • Plitman E; Psychotic Disorders Division, McLean Hospital, Harvard Medical School, Belmont, Massachusetts.
  • Posporelis S; Editor, JAMA Psychiatry.
  • Purdon SE; National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
  • Reichenbach JR; Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada.
  • Renshaw PF; Department of Psychiatry, Western University, London, Ontario, Canada.
  • Russell BR; Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Carlton, Victoria, Australia.
  • Sawa A; The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.
JAMA Psychiatry ; 78(6): 667-681, 2021 06 01.
Article in En | MEDLINE | ID: mdl-33881460
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Schizophrenia / Antipsychotic Agents / Brain / Glutamic Acid Type of study: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Aspects: Patient_preference Limits: Adult / Female / Humans / Male Language: En Journal: JAMA Psychiatry Year: 2021 Document type: Article Affiliation country: United kingdom
Fulltext
Add to My VHL
Print
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Schizophrenia / Antipsychotic Agents / Brain / Glutamic Acid Type of study: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Aspects: Patient_preference Limits: Adult / Female / Humans / Male Language: En Journal: JAMA Psychiatry Year: 2021 Document type: Article Affiliation country: United kingdom