Direct Conjugation of NEDD8 to the N-Terminus of a Model Protein Can Induce Degradation.

Vijayasimha, Kartikeya; Tran, Marilyn Vo; Leestemaker-Palmer, Amy L; Dolan, Brian P

Vijayasimha, Kartikeya; Tran, Marilyn Vo; Leestemaker-Palmer, Amy L; Dolan, Brian P.

Affiliation

Vijayasimha K; Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.
Tran MV; Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.
Leestemaker-Palmer AL; Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.
Dolan BP; Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.

Cells ; 10(4)2021 04 09.

Article in En | MEDLINE | ID: mdl-33918652

Subject(s)

Green Fluorescent Proteins/metabolism; NEDD8 Protein/metabolism; Proteolysis; Recombinant Fusion Proteins/chemistry; Recombinant Fusion Proteins/metabolism; Animals; Autophagosomes/metabolism; Cell Line; Fluorescence; Half-Life; Humans; Mice; Proteasome Endopeptidase Complex/metabolism; Protein Folding/drug effects; Pyrazoles/pharmacology; Pyrimidines/pharmacology; Sulfides/pharmacology; Sulfonamides/pharmacology; Ubiquitin/metabolism; Ubiquitination/drug effects

Key words

NEDD8; proteasome; protein degradation; ubiquitination

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Fusion Proteins / Green Fluorescent Proteins / Proteolysis / NEDD8 Protein Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cells Year: 2021 Document type: Article Affiliation country: United States Country of publication: Switzerland

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google