Arthropod Ectoparasites Have Potential to Bind SARS-CoV-2 via ACE.
Viruses
; 13(4)2021 04 19.
Article
in En
| MEDLINE
| ID: mdl-33921873
ABSTRACT
Coronavirus-like organisms have been previously identified in Arthropod ectoparasites (such as ticks and unfed cat flea). Yet, the question regarding the possible role of these arthropods as SARS-CoV-2 passive/biological transmission vectors is still poorly explored. In this study, we performed in silico structural and binding energy calculations to assess the risks associated with possible ectoparasite transmission. We found sufficient similarity between ectoparasite ACE and human ACE2 protein sequences to build good quality 3D-models of the SARS-CoV-2 SpikeACE complex to assess the impacts of ectoparasite mutations on complex stability. For several species (e.g., water flea, deer tick, body louse), our analyses showed no significant destabilisation of the SARS-CoV-2 SpikeACE complex, suggesting these species would bind the viral Spike protein. Our structural analyses also provide structural rationale for interactions between the viral Spike and the ectoparasite ACE proteins. Although we do not have experimental evidence of infection in these ectoparasites, the predicted stability of the complex suggests this is possible, raising concerns of a possible role in passive transmission of the virus to their human hosts.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arthropods
/
Peptidyl-Dipeptidase A
/
Arthropod Proteins
/
SARS-CoV-2
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Viruses
Year:
2021
Document type:
Article
Affiliation country:
United kingdom