Emerging Roles of Gut Virome in Pediatric Diseases.
Int J Mol Sci
; 22(8)2021 Apr 16.
Article
in En
| MEDLINE
| ID: mdl-33923593
ABSTRACT
In the last decade, the widespread application of shotgun metagenomics provided extensive characterization of the bacterial "dark matter" of the gut microbiome, propelling the development of dedicated, standardized bioinformatic pipelines and the systematic collection of metagenomic data into comprehensive databases. The advent of next-generation sequencing also unravels a previously underestimated viral population (virome) present in the human gut. Despite extensive efforts to characterize the human gut virome, to date, little is known about the childhood gut virome. However, alterations of the gut virome in children have been linked to pathological conditions such as inflammatory bowel disease, type 1 diabetes, malnutrition, diarrhea and celiac disease.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Inflammatory Bowel Diseases
/
Celiac Disease
/
Diabetes Mellitus, Type 1
/
Diarrhea
/
Virome
/
Intestinal Mucosa
Limits:
Child
/
Humans
Language:
En
Journal:
Int J Mol Sci
Year:
2021
Document type:
Article
Affiliation country:
Italy