N-acetylcysteine facilitates extinction of cued fear memory in rats via reestablishing basolateral amygdala glutathione homeostasis.

Wu, Peng-Fei; Guan, Xin-Lei; Wang, Fang; Chen, Jian-Guo

Wu, Peng-Fei; Guan, Xin-Lei; Wang, Fang; Chen, Jian-Guo.

Affiliation

Wu PF; Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Guan XL; Key Laboratory of Neurological Diseases (HUST), Ministry of Education of China, Wuhan, 430030, China.
Wang F; The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan, 430030, China.
Chen JG; Laboratory of Neuropsychiatric Diseases, The Institute of Brain Research, Huazhong University of Science and Technology, Wuhan, 430030, China.

Acta Pharmacol Sin ; 43(2): 260-272, 2022 Feb.

Article in En | MEDLINE | ID: mdl-33927360

Subject(s)

Acetylcysteine/pharmacology; Basolateral Nuclear Complex/drug effects; Extinction, Psychological/drug effects; Fear/drug effects; Glutathione/metabolism; Memory/drug effects; Animals; Basolateral Nuclear Complex/metabolism; Basolateral Nuclear Complex/physiology; Buthionine Sulfoximine/pharmacology; Conditioning, Classical; Cues; Dithiothreitol/pharmacology; Glutathione/physiology; Homeostasis/drug effects; Male; Rats; Rats, Sprague-Dawley

Key words

N-acetylcysteine; NMDAR; basolateral amygdale; buthionine sulfoximine; dithiothreitol; fear extinction; fear-related anxiety disorders; glutathione; oxidative stress; synaptic plasticity; transverse LA slices

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetylcysteine / Extinction, Psychological / Fear / Basolateral Nuclear Complex / Glutathione / Memory Limits: Animals Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2022 Document type: Article Affiliation country: China

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