Autophagy in axonal and presynaptic development.
Curr Opin Neurobiol
; 69: 139-148, 2021 08.
Article
in En
| MEDLINE
| ID: mdl-33940492
ABSTRACT
The study of autophagy in the nervous system has predominantly centered on degeneration. Evidence is now cementing crucial roles for autophagy in neuronal development and growth, especially in axonal and presynaptic compartments. A picture is emerging that autophagy typically promotes the growth of axons and reduces presynaptic stability. Nonetheless, these are not rigid principles, and it remains unclear why autophagy does not always display these relationships during axonal and presynaptic development. Recent progress has identified mechanisms underlying spatiotemporal control of autophagy in neurons and begun to unravel how autophagy is integrated with other cellular processes, such as proteasomal degradation and axon guidance. Ultimately, understanding how autophagy is regulated and its role in the developing nervous system is key to comprehending how the nervous system assembles its stereotyped yet plastic configuration. It is also likely to inform how we think about neurodevelopmental disorders and neurodegenerative diseases.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Axons
/
Neurodegenerative Diseases
Limits:
Humans
Language:
En
Journal:
Curr Opin Neurobiol
Journal subject:
BIOLOGIA
/
NEUROLOGIA
Year:
2021
Document type:
Article