Single- and Multiple-Dose Pharmacokinetics and Pharmacodynamics of PN-943, a Gastrointestinal-Restricted Oral Peptide Antagonist of &#945;4ß7, in Healthy Volunteers.

Modi, Nishit B; Cheng, Xiaoli; Mattheakis, Larry; Hwang, Ching-Chang; Nawabi, Roya; Liu, David; Gupta, Suneel

Single- and Multiple-Dose Pharmacokinetics and Pharmacodynamics of PN-943, a Gastrointestinal-Restricted Oral Peptide Antagonist of α4ß7, in Healthy Volunteers.

Modi, Nishit B; Cheng, Xiaoli; Mattheakis, Larry; Hwang, Ching-Chang; Nawabi, Roya; Liu, David; Gupta, Suneel.

Affiliation

Modi NB; Protagonist Therapeutics, Inc, Newark, California, USA.
Cheng X; Protagonist Therapeutics, Inc, Newark, California, USA.
Mattheakis L; Protagonist Therapeutics, Inc, Newark, California, USA.
Hwang CC; Protagonist Therapeutics, Inc, Newark, California, USA.
Nawabi R; Protagonist Therapeutics, Inc, Newark, California, USA.
Liu D; Protagonist Therapeutics, Inc, Newark, California, USA.
Gupta S; Protagonist Therapeutics, Inc, Newark, California, USA.

Clin Pharmacol Drug Dev ; 10(11): 1263-1278, 2021 11.

Article in En | MEDLINE | ID: mdl-33942566

Subject(s)

Gastrointestinal Agents/pharmacokinetics; Integrins/antagonists & inhibitors; Administration, Oral; Adult; Cross-Over Studies; Dose-Response Relationship, Drug; Fasting; Food-Drug Interactions; Gastrointestinal Absorption; Gastrointestinal Agents/blood; Healthy Volunteers; Humans; Inflammatory Bowel Diseases/drug therapy; Male; Meals

Key words

PN-943; gastrointestinal restricted; pharmacodynamics; pharmacokinetics; α4ß7 antagonist

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gastrointestinal Agents / Integrins Type of study: Clinical_trials Limits: Adult / Humans / Male Language: En Journal: Clin Pharmacol Drug Dev Year: 2021 Document type: Article Affiliation country: United States Country of publication: United States

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