The Route of Early T Cell Development: Crosstalk between Epigenetic and Transcription Factors.
Cells
; 10(5)2021 04 30.
Article
in En
| MEDLINE
| ID: mdl-33946533
ABSTRACT
Hematopoietic multipotent progenitors seed the thymus and then follow consecutive developmental stages until the formation of mature T cells. During this process, phenotypic changes of T cells entail stage-specific transcriptional programs that underlie the dynamic progression towards mature lymphocytes. Lineage-specific transcription factors are key drivers of T cell specification and act in conjunction with epigenetic regulators that have also been elucidated as crucial players in the establishment of regulatory networks necessary for proper T cell development. In this review, we summarize the activity of transcription factors and epigenetic regulators that together orchestrate the intricacies of early T cell development with a focus on regulation of T cell lineage commitment.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transcription Factors
/
T-Lymphocytes
/
Lymphopoiesis
/
Epigenesis, Genetic
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Cells
Year:
2021
Document type:
Article
Affiliation country:
Netherlands
Publication country:
CH
/
SUIZA
/
SUÍÇA
/
SWITZERLAND