Rapid Increase of Gastrointestinal P-Glycoprotein Functional Activity in Response to Etoposide Stimulation.

Yano, Kentaro; Kimura, Masaki; Watanabe, Yayoi; Ogihara, Takuo

Yano, Kentaro; Kimura, Masaki; Watanabe, Yayoi; Ogihara, Takuo.

Affiliation

Yano K; Laboratory of Drug Metabolism and Pharmacokinetics, Yokohama University of Pharmacy.
Kimura M; Laboratory of Biopharmaceutics, Department of Pharmacology, Takasaki University of Health and Welfare.
Watanabe Y; Laboratory of Biopharmaceutics, Department of Pharmacology, Takasaki University of Health and Welfare.
Ogihara T; Laboratory of Biopharmaceutics, Department of Pharmacology, Takasaki University of Health and Welfare.

Biol Pharm Bull ; 44(5): 701-706, 2021.

Article in En | MEDLINE | ID: mdl-33952826

Subject(s)

Etoposide/pharmacology; ATP Binding Cassette Transporter, Subfamily B/antagonists & inhibitors; ATP Binding Cassette Transporter, Subfamily B/metabolism; Benzodiazepines/pharmacology; Caco-2 Cells; Cell Membrane/drug effects; Cell Membrane/metabolism; Cholecystokinin/metabolism; Cytoskeletal Proteins/metabolism; Humans; Membrane Proteins/metabolism; Microfilament Proteins/metabolism; Phosphorylation/drug effects; Receptor, Cholecystokinin B/antagonists & inhibitors; Receptor, Cholecystokinin B/metabolism

Key words

P-glycoprotein (P-gp); cholecystokinin; etoposide; ezrin radixin moesin (ERM) protein; human colon adenocarcinoma (Caco-2) cell; membrane localization

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Etoposide Limits: Humans Language: En Journal: Biol Pharm Bull Journal subject: BIOQUIMICA / FARMACOLOGIA Year: 2021 Document type: Article

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