Angiotensin (1-7) Attenuates the Nociceptive Behavior Induced by Substance P and NMDA via Spinal MAS1.

Yamagata, Ryota; Nemoto, Wataru; Fujita, Maho; Nakagawasai, Osamu; Tan-No, Koichi

Yamagata, Ryota; Nemoto, Wataru; Fujita, Maho; Nakagawasai, Osamu; Tan-No, Koichi.

Affiliation

Yamagata R; Division of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University.
Nemoto W; Division of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University.
Fujita M; Division of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University.
Nakagawasai O; Division of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University.
Tan-No K; Division of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University.

Biol Pharm Bull ; 44(5): 742-746, 2021.

Article in En | MEDLINE | ID: mdl-33952831

Subject(s)

Angiotensin I/administration & dosage; Nociception/drug effects; Nociceptive Pain/drug therapy; Peptide Fragments/administration & dosage; Proto-Oncogene Proteins/agonists; Receptors, G-Protein-Coupled/agonists; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Injections, Spinal; Male; Mice; N-Methylaspartate/administration & dosage; N-Methylaspartate/adverse effects; Nociceptive Pain/chemically induced; Nociceptive Pain/diagnosis; Proto-Oncogene Mas; Proto-Oncogene Proteins/metabolism; Receptors, G-Protein-Coupled/metabolism; Receptors, N-Methyl-D-Aspartate/metabolism; Receptors, Neurokinin-1/metabolism; Spinal Cord/drug effects; Spinal Cord/metabolism; Substance P/administration & dosage; Substance P/adverse effects

Key words

MAS1; N-methyl-D-aspartate; angiotensin (17); spinal cord; substance P

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Angiotensin I / Proto-Oncogene Proteins / Receptors, G-Protein-Coupled / Nociceptive Pain / Nociception Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Biol Pharm Bull Journal subject: BIOQUIMICA / FARMACOLOGIA Year: 2021 Document type: Article Country of publication: Japan

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