Simple TLC-spectrodensitometric method for studying lipophilicity and quantitative analysis of hypoglycemic drugs in their binary mixture.

Abbas, Noha S; Mohamed, Yahya Abduh Salim; Derayea, Sayed M; Omar, Mahmoud A; Saleh, Gamal A

Abbas, Noha S; Mohamed, Yahya Abduh Salim; Derayea, Sayed M; Omar, Mahmoud A; Saleh, Gamal A.

Affiliation

Abbas NS; Ministry of Health and Population, Assiut, Egypt.
Mohamed YAS; Department of Medicinal and Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Sana'a University, 464414, Yemen.
Derayea SM; Department of Analytical Chemistry, Faculty of Pharmacy, Minia University, 61519, Egypt.
Omar MA; Department of Analytical Chemistry, Faculty of Pharmacy, Minia University, 61519, Egypt.
Saleh GA; Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Madinah, Saudi Arabia.

Biomed Chromatogr ; 35(11): e5154, 2021 Nov.

Article in En | MEDLINE | ID: mdl-33955025

Subject(s)

Chromatography, Thin Layer/methods; Hypoglycemic Agents/analysis; Hypoglycemic Agents/chemistry; Benzhydryl Compounds/analysis; Benzhydryl Compounds/chemistry; Densitometry; Glucosides/analysis; Glucosides/chemistry; Humans; Hydrophobic and Hydrophilic Interactions; Limit of Detection; Linear Models; Metformin/analysis; Metformin/chemistry; Reproducibility of Results; Tablets/chemistry

Key words

dapagliflozin; metformin HCl; molecular lipophilicity; salting-out-assisted TLC

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromatography, Thin Layer / Hypoglycemic Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: Biomed Chromatogr Year: 2021 Document type: Article Affiliation country: Egypt Country of publication: United kingdom

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