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Therapeutically reprogrammed nutrient signalling enhances nanoparticulate albumin bound drug uptake and efficacy in KRAS-mutant cancer.
Li, Ran; Ng, Thomas S C; Wang, Stephanie J; Prytyskach, Mark; Rodell, Christopher B; Mikula, Hannes; Kohler, Rainer H; Garlin, Michelle A; Lauffenburger, Douglas A; Parangi, Sareh; Dinulescu, Daniela M; Bardeesy, Nabeel; Weissleder, Ralph; Miller, Miles A.
Affiliation
  • Li R; Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA, USA.
  • Ng TSC; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Wang SJ; Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA, USA.
  • Prytyskach M; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Rodell CB; Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA, USA.
  • Mikula H; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Kohler RH; Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA, USA.
  • Garlin MA; Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA, USA.
  • Lauffenburger DA; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, USA.
  • Parangi S; Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA, USA.
  • Dinulescu DM; Institute of Applied Synthetic Chemistry, Vienna University of Technology (TU Wien), Vienna, Austria.
  • Bardeesy N; Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA, USA.
  • Weissleder R; Center for Systems Biology, Massachusetts General Hospital Research Institute, Boston, MA, USA.
  • Miller MA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nat Nanotechnol ; 16(7): 830-839, 2021 07.
Article in En | MEDLINE | ID: mdl-33958764
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins p21(ras) / Paclitaxel / MAP Kinase Signaling System / Nanoparticles / Serum Albumin, Human / Mutation / Neoplasms, Experimental Limits: Animals / Humans Language: En Journal: Nat Nanotechnol Year: 2021 Document type: Article Affiliation country: United States Country of publication: United kingdom
Fulltext
Add to My VHL
Print
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins p21(ras) / Paclitaxel / MAP Kinase Signaling System / Nanoparticles / Serum Albumin, Human / Mutation / Neoplasms, Experimental Limits: Animals / Humans Language: En Journal: Nat Nanotechnol Year: 2021 Document type: Article Affiliation country: United States Country of publication: United kingdom