Nuclear matrix-intermediate filament system and its alteration in adenovirus infected HeLa cell.
Cell Biol Int Rep
; 12(2): 99-108, 1988 Feb.
Article
in En
| MEDLINE
| ID: mdl-3396082
ABSTRACT
The nuclear matrix-intermediate filament (NM-IF) of normal and adenovirus infected HeLa cells were investigated by means of both electron microscopy and two-dimensional gel electrophoresis. After infection there were some changes in NM-IF, and the viral factory was suspended in nuclear matrix. Two new polypeptides appeared in 2-D gel of NM-IF after infection. They are probably not viral proteins but cellular polypeptides. During viral replication, all of vimentin were degraded and phosphorylated keratin 18 increased. These facts suggest that NM-IF plays a certain role in adenovirus replication.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cytoskeleton
/
Intermediate Filaments
/
Cell Nucleus
/
Adenoviruses, Human
Limits:
Humans
Language:
En
Journal:
Cell Biol Int Rep
Year:
1988
Document type:
Article