The molecular targets of taurine confer anti-hyperlipidemic effects.
Life Sci
; 278: 119579, 2021 Aug 01.
Article
in En
| MEDLINE
| ID: mdl-33961852
ABSTRACT
Hyperlipidemia, an independent risk factor for atherosclerosis, is regarded as a lipid metabolism disorder associated with elevated plasma triglyceride and/or cholesterol. Genetic factors and unhealthy lifestyles, such as excess caloric intake and physical inactivity, can result in hyperlipidemia. Taurine, a sulfur-containing non-essential amino acid, is abundant in marine foods and has been associated with wide-ranging beneficial physiological effects, with special reference to regulating aberrant lipid metabolism. Its anti-hyperlipidemic mechanism is complex, which is related to many enzymes in the process of fat anabolism and catabolism (e.g., HMGCR, CYP7A1, LDLR, FXR, FAS and ACC). Anti-inflammatory and antioxidant molecular targets, lipid autophagy, metabolic reprogramming and gut microbiota will also be reviewed.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Taurine
/
Hyperlipidemias
Type of study:
Risk_factors_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Life Sci
Year:
2021
Document type:
Article
Affiliation country:
China