Deletion of the last two exons of FGF10 in a family with LADD syndrome and pulmonary acinar hypoplasia.
Eur J Hum Genet
; 30(4): 480-484, 2022 04.
Article
in En
| MEDLINE
| ID: mdl-33967277
ABSTRACT
Pulmonary acinar hypoplasia (PAH) and lacrimo-auriculo-dento-digital (LADD) syndrome have both been associated with loss-of-function variants in, or deletions of FGF10. Here we report a multi-generational family with seven members manifesting varying features of LADD syndrome, with one individual dying in early infancy of PAH. Whole genome sequencing in one family member identified a 12,158 bp deletion on chromosome 5p12 that removes two of the three exons of FGF10. Allele-specific PCR demonstrated that all affected family members, including the individual with PAH, carried the 12 kb deletion. We conclude the deletion is pathogenic and expands the mutational spectrum of FGF10 variants in LADD syndrome. The common mechanism underlying the variable clinical features of LADD syndrome is defective terminal branching of salivary and lacrimal glands and pulmonary acini, regulated by the TBX4-FGF10-FGFR2 pathway. The variable phenotypic expressivity of FGF10 haploinsufficiency from relatively benign to lethal is likely due to variation at other genetic loci.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tooth Abnormalities
/
Syndactyly
/
Fibroblast Growth Factor 10
/
Lacrimal Apparatus Diseases
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Eur J Hum Genet
Journal subject:
GENETICA MEDICA
Year:
2022
Document type:
Article
Affiliation country:
New Zealand