Prostaglandin cytoprotection in man: effectiveness of rosaprostol.
Int J Tissue React
; 10(1): 53-7, 1988.
Article
in En
| MEDLINE
| ID: mdl-3397253
ABSTRACT
We studied the effect of a new prostaglandin analogue, 9-hydroxy-19,20-bis-norprostanoic acid (rosaprostol), on the duodenal mucosa of humans after administration of 40% ethanol. Eighteen healthy volunteers entered the study, which followed a blind cross-over design. At time 0 all the volunteers received rosaprostol or placebo; 5 minutes later, 40% ethanol (50 ml dose) was given. The mucosa was examined for lesions 3, 60 and 180 min later under endoscopy, light and scanning microscopy. It was found that (i) 40% ethanol damaged the duodenum, with blood extravasation, inflammation and necrosis of the mucosa, (ii) rosaprostol significantly protected the mucosa 3 min after 40% ethanol, and (iii) the damage became worse after 3 h when placebo was given, whereas it was reduced after 1 h when PG was administered. The results suggest that PGs not only protect the mucosa against ethanol damage, but also stimulate its recovery.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prostaglandins, Synthetic
/
Prostanoic Acids
/
Fatty Acids
/
Intestinal Mucosa
Type of study:
Clinical_trials
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Int J Tissue React
Year:
1988
Document type:
Article
Affiliation country:
Italy