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The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4.
Cai, Xingguang; Javor, Sacha; Gan, Bee Ha; Köhler, Thilo; Reymond, Jean-Louis.
Affiliation
  • Cai X; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland. jean-louis.reymond@dcb.unibe.ch.
  • Javor S; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland. jean-louis.reymond@dcb.unibe.ch.
  • Gan BH; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland. jean-louis.reymond@dcb.unibe.ch.
  • Köhler T; Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland.
  • Reymond JL; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland. jean-louis.reymond@dcb.unibe.ch.
Chem Commun (Camb) ; 57(46): 5654-5657, 2021 Jun 08.
Article in En | MEDLINE | ID: mdl-33972964
pH-activity profiling reveals that antimicrobial peptide dendrimers (AMPDs) kill Klebsiella pneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA) at pH = 8.0, against which they are inactive at pH = 7.4, due to stronger electrostatic binding to bacterial cells at higher pH. A similar effect occurs with polymyxin B and might be general for polycationic antimicrobials.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Polymyxin B / Dendrimers / Methicillin-Resistant Staphylococcus aureus / Klebsiella pneumoniae / Anti-Bacterial Agents Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2021 Document type: Article Affiliation country: Switzerland Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Polymyxin B / Dendrimers / Methicillin-Resistant Staphylococcus aureus / Klebsiella pneumoniae / Anti-Bacterial Agents Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2021 Document type: Article Affiliation country: Switzerland Country of publication: United kingdom