Critical Determinants of Cytokine Storm and Type I Interferon Response in COVID-19 Pathogenesis.

Ramasamy, Santhamani; Subbian, Selvakumar

Ramasamy, Santhamani; Subbian, Selvakumar.

Affiliation

Ramasamy S; Public Health Research Institute (PHRI) at New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Subbian S; Public Health Research Institute (PHRI) at New Jersey Medical School, Rutgers University, Newark, New Jersey, USA subbiase@njms.rutgers.edu.

Clin Microbiol Rev ; 34(3)2021 06 16.

Article in En | MEDLINE | ID: mdl-33980688

Subject(s)

COVID-19/pathology; Cytokine Release Syndrome/blood; Cytokine Release Syndrome/pathology; Interferon Type I/blood; SARS-CoV-2/immunology; Angiotensin-Converting Enzyme 2/metabolism; COVID-19/blood; COVID-19/therapy; Comorbidity; Humans; Immunity, Innate/immunology; Immunization, Passive/methods; Interleukin-6/antagonists & inhibitors; Interleukin-6/blood; Spike Glycoprotein, Coronavirus/metabolism; COVID-19 Serotherapy

Key words

ACE2; SARS-CoV-2; antibodies; cell surface receptors; comorbidities; inflammation; innate immunity; interferon; intracellular signaling; proinflammatory cytokines

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interferon Type I / Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 Type of study: Etiology_studies / Prognostic_studies Limits: Humans Language: En Journal: Clin Microbiol Rev Journal subject: MICROBIOLOGIA Year: 2021 Document type: Article Affiliation country: United States Country of publication: United States

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