Amyloid-ß Oligomers Induce Only Mild Changes to Inhibitory Bouton Dynamics.
J Alzheimers Dis Rep
; 5(1): 153-160, 2021 Feb 27.
Article
in En
| MEDLINE
| ID: mdl-33981952
ABSTRACT
The amyloid-ß protein precursor is highly expressed in a subset of inhibitory neuron in the hippocampus, and inhibitory neurons have been suggested to play an important role in early Alzheimer's disease plaque load. Here we investigated bouton dynamics in axons of hippocampal interneurons in two independent amyloidosis models. Short-term (24âh) amyloid-ß (Aß)-oligomer application to organotypic hippocampal slices slightly increased inhibitory bouton dynamics, but bouton density and dynamics were unchanged in hippocampus slices of young-adult App NL - F - G -mice, in which Aß levels are chronically elevated. These results indicate that loss or defective adaptation of inhibitory synapses are not a major contribution to Aß-induced hyperexcitability.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Alzheimers Dis Rep
Year:
2021
Document type:
Article
Affiliation country:
Netherlands