Impact of an alpha helix and a cysteine-cysteine disulfide bond on the resistance of bacterial adhesion pili to stress.

Baker, Joseph L; Dahlberg, Tobias; Bullitt, Esther; Andersson, Magnus

Baker, Joseph L; Dahlberg, Tobias; Bullitt, Esther; Andersson, Magnus.

Affiliation

Baker JL; Department of Chemistry, The College of New Jersey, Ewing, NJ 08628; bakerj@tcnj.edu magnus.andersson@umu.se.
Dahlberg T; Department of Physics, Umeå University, Umeå 90187, Sweden.
Bullitt E; Department of Physiology & Biophysics, Boston University School of Medicine, Boston, MA 02118.
Andersson M; Department of Physics, Umeå University, Umeå 90187, Sweden; bakerj@tcnj.edu magnus.andersson@umu.se.

Proc Natl Acad Sci U S A ; 118(21)2021 05 25.

Article in En | MEDLINE | ID: mdl-34011607

Subject(s)

Adhesins, Escherichia coli/chemistry; Enterotoxigenic Escherichia coli/ultrastructure; Fimbriae Proteins/chemistry; Fimbriae, Bacterial/ultrastructure; Uropathogenic Escherichia coli/ultrastructure; Adhesins, Escherichia coli/genetics; Adhesins, Escherichia coli/metabolism; Bacterial Adhesion; Binding Sites; Biomechanical Phenomena; Cysteine/chemistry; Cysteine/metabolism; Disulfides/chemistry; Disulfides/metabolism; Enterotoxigenic Escherichia coli/genetics; Enterotoxigenic Escherichia coli/metabolism; Fimbriae Proteins/genetics; Fimbriae Proteins/metabolism; Fimbriae, Bacterial/genetics; Fimbriae, Bacterial/metabolism; Gene Expression; Kinetics; Molecular Dynamics Simulation; Optical Tweezers; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Protein Structure, Tertiary; Protein Subunits/chemistry; Protein Subunits/genetics; Protein Subunits/metabolism; Thermodynamics; Uropathogenic Escherichia coli/genetics; Uropathogenic Escherichia coli/metabolism

Key words

ETEC; UPEC; optical tweezers; sequence homology; steered molecular dynamics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fimbriae, Bacterial / Adhesins, Escherichia coli / Fimbriae Proteins / Enterotoxigenic Escherichia coli / Uropathogenic Escherichia coli Language: En Journal: Proc Natl Acad Sci U S A Year: 2021 Document type: Article Country of publication: United States

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