Gastrointestinal Factors Associated With Hospitalization in Infants With Cystic Fibrosis: Results From the Baby Observational and Nutrition Study.
J Pediatr Gastroenterol Nutr
; 73(3): 395-402, 2021 09 01.
Article
in En
| MEDLINE
| ID: mdl-34016873
ABSTRACT
OBJECTIVES:
To identify factors that increase the risk of gastrointestinal-related (GI-related) hospitalization of infants with cystic fibrosis (CF) during the first year of life.METHODS:
The Baby Observational and Nutrition Study was a longitudinal, observational cohort of 231 infants diagnosed with CF by newborn screening. We performed a post-hoc assessment of the frequency and indications for GI-related admissions during the first year of life.RESULTS:
Sixty-five participants had at least one admission in the first 12âmonths of life. High pancreatic enzyme replacement therapy (PERT) dosing (>2000âlipase units/kg per meal; hazard ratio [HR]â=â14.75, Pâ=â0.0005) and use of acid suppressive medications (HRâ=â4.94, Pâ=â0.01) during the study period were positively associated with subsequent GI-related admissions. High levels of fecal calprotectin (fCP) (>200âµg/g) and higher relative abundance of fecal Klebsiella pneumoniae were also positively associated with subsequent GI-related admissions (HRâ=â2.64, Pâ=â0.033 and HRâ=â4.49, Pâ=â0.002, respectively). During the first 12âmonths of life, participants with any admission had lower weight-for-length z scores (WLZ) (Pâ=â0.01). The impact of admission on WLZ was particularly evident in participants with a GI-related admission (Pâ<â0.0001).CONCLUSIONS:
Factors associated with a higher risk for GI-related admission during the first 12âmonths include high PERT dosing, exposure to acid suppressive medications, higher fCP levels, and/or relative abundance of fecal K pneumoniae early in life. Infants with CF requiring GI-related hospitalization had lower WLZ at 12âmonths of age than those not admitted as well as those admitted for non-GI-related indications.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cystic Fibrosis
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
/
Infant
/
Newborn
Language:
En
Journal:
J Pediatr Gastroenterol Nutr
Year:
2021
Document type:
Article