A systematic review of preclinical data regarding commercial silver-coated vascular grafts.
J Vasc Surg
; 74(4): 1386-1393.e1, 2021 10.
Article
in En
| MEDLINE
| ID: mdl-34019984
ABSTRACT
OBJECTIVE:
Vascular graft infection (VGI) is a serious complication with high mortality and morbidity rates. Several measures could be taken to decrease this risk, including the use of silver-containing vascular grafts. However, to date, no clinical advantages have been reported. This study reviews the outcome of preclinical studies focusing on the role of commercially available silver-coated grafts in the prevention of VGI.METHODS:
A systematic review was performed with a focus on the preclinical role of commercially available silver-coated vascular grafts in the prevention and treatment of VGI. A comprehensive search was conducted in Medline, Embase, and Web of Science.RESULTS:
Nine in vitro and five in vivo studies were included. Two commercial grafts were used (INTERGARD SILVER and Silver Graft). In vitro studies used both gram-positive and gram-negative strains. A positive antimicrobial effect was observed in seven of nine studies (77.8%). A delayed antifungal effect against Candida species was observed in vitro, but disappeared when adding serum proteins. In vivo studies witnessed a microbicidal effect in two out of five studies (40%), but only tested a single causative pathogen (ie, Staphylococcus aureus).CONCLUSIONS:
Both in vitro and in vivo studies demonstrated conflicting and mixed results concerning the antimicrobial efficacy of commercially available silver-containing grafts in the prevention of VGI. In general, the study setup was heterogeneous in the different articles. Given the lack of convincing preclinical evidence and their poor performance in clinical studies, more data are needed at this time to guide the appropriate use of silver grafts.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood Vessel Prosthesis
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Prosthesis-Related Infections
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Silver Compounds
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Blood Vessel Prosthesis Implantation
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Coated Materials, Biocompatible
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Endovascular Procedures
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Anti-Bacterial Agents
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Antifungal Agents
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Systematic_reviews
Limits:
Animals
/
Humans
Language:
En
Journal:
J Vasc Surg
Journal subject:
ANGIOLOGIA
Year:
2021
Document type:
Article
Publication country:
EEUU
/
ESTADOS UNIDOS
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ESTADOS UNIDOS DA AMERICA
/
EUA
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UNITED STATES
/
UNITED STATES OF AMERICA
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US
/
USA