[Application of continuous renal replacement therapy in the treatment of neonates with inherited metabolic diseases].
Zhongguo Dang Dai Er Ke Za Zhi
; 23(5): 488-493, 2021 May.
Article
in Zh
| MEDLINE
| ID: mdl-34020739
ABSTRACT
OBJECTIVE:
To study the efficacy and safety of continuous renal replacement therapy (CRRT) in the treatment of neonates with inherited metabolic diseases and hyperammonemia.METHODS:
A retrospective analysis was performed on the medical records of neonates with inherited metabolic diseases and hyperammonemia who were hospitalized and underwent CRRT in the Department of Neonatology, Hunan Children's Hospital, from September 2016 to March 2020, including general conditions, clinical indices, laboratory markers, and adverse reactions.RESULTS:
A total of 11 neonates were enrolled, with 7 boys (64%) and 4 girls (36%). The neonates had a mean gestational age of (38.9±0.8) weeks, a mean body weight of (3 091±266) g on admission, and an age of (5.7±2.0) days at the time of CRRT. The main clinical manifestations were vomiting (100%), convulsions (100%), and coma (55%), and the main primary disease was urea cycle disorder (55%). The mean duration of CRRT was (44±14) hours, the medium duration of coma before CRRT was 2 hours, and the total duration of coma was 10 hours. The patients had a mean hospital stay of (18±10) days and a survival rate of 73%, and 2 survivors had epilepsy. After treatment, all patients had significant reductions in blood ammonia, lactic acid, and K+ concentration (P < 0.001) and a significant increase in pH (P < 0.001). The incidence rate of adverse reactions was 27%.CONCLUSIONS:
CRRT is safe and effective in the treatment of neonates with inherited metabolic diseases and hyperammonemia.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hyperammonemia
/
Acute Kidney Injury
/
Continuous Renal Replacement Therapy
/
Metabolic Diseases
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Child
/
Female
/
Humans
/
Infant
/
Male
/
Newborn
Language:
Zh
Journal:
Zhongguo Dang Dai Er Ke Za Zhi
Year:
2021
Document type:
Article
Affiliation country:
China