The prenatal phase of retinopathy of prematurity.
Acta Paediatr
; 110(9): 2521-2528, 2021 Sep.
Article
in En
| MEDLINE
| ID: mdl-34028096
ABSTRACT
AIM:
To explore the current literature on prenatal inflammation-associated risk factors for retinopathy of prematurity (ROP).METHODS:
Subjective summary of selected experimental and epidemiological publications that support the authors' central hypothesis that the aetiology of ROP begins before birth.RESULTS:
Based on current evidence we suggest that, contrary to current aetiological models, the process of ROP development begins with a prephase in utero. This beginning is likely initiated by inflammatory responses that are associated with intrauterine infection.CONCLUSION:
We propose a novel aetio-pathogenetic model of ROP and suggest that the effects of postnatal exposure to inflammatory stressors (resulting from infection or hyperoxia or both) as well as those of other pre- and postnatal contributors to the complex pathogenesis of ROP might be modified by the prenatal phase of the disease.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Retinopathy of Prematurity
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Newborn
/
Pregnancy
Language:
En
Journal:
Acta Paediatr
Year:
2021
Document type:
Article
Affiliation country:
United States